What is the amp doing when the resistors blow?
Without a signal, the TDA2050 amps have a 60mA corrent drain. That is only 8mW in each resistor.
With the amp at full output, the max voltage across each resistor is only about 1.2V, so each resistor dissipates only 655mW for half the time, so 1/2W resistors should be fine.
Did you insulate the amp ICs from the heatsinks?
Are the heatsinks insulatoed from each other?
What is your DC supply voltage?
Are the pins on the transistors connected correctly?