Analog to digital signal conditioning

[TriggerShock]

If I have a 12 bit ADC with a reference voltage of 4.096V it should be able to detect changes in voltage up to 1mV correct?

However when you attenuate a signal that is much larger than Vref, you are not going to get nice 1mv steps. What are the considerations one should make to help mitigate the differences to acheive the greatest accuracy/precision.

 

[Hero999]

The ADC will always be as accurate as the voltage you want to measure divided by 4096. Dividing, amplifying and level shifting will always introduce more error which will depend on the quality of the components used.