The company I work for recently dumped PCAD in favor of PADS.... I liked both, but prefer PADS. I suppose it's what your use too. I did find it easier to make "intelegent" schematics in PADS when linking to the layout.
As for simulators... Orcad, MicroSim, Intusoft and Workbench. My vote goes to MicroSim and Intusoft, but quite often I have convergence problems with both. Like anything else, you get what you pay for. The simulation is only as good as the models. I've yet to see anyone with a good overall model set. Most seem to be good in one or two areas, but poor in others..... for example, they have a great MOSFET and PWM selection, but the magnetics models stink!!! Intusoft is kinda neat in that they have a magnetics design program and the model can be linked to their simulation program.