Kain,
In short, No.
(over simplified-----) Basicly, regardless of type, ROM's are just that- Read Only Memory. You supply an address, and the data is what you have programmed into that address. If there is a point in the rom that you do not want to use, or "don't care" what it has, don't use it. There MAY be packages where there is a pin or two that may have a "don't care" situation, I think durring the programming of the EEPROM there is an input or two that sit's in a "don't care" situation, but that condition does not exist durring normal operation.
oldgrandpainmi