If you are using the values shown on your simulation, then feedback resistors R5 and R6 are incorrect. With the values shown, 220K and 5K the gain of your circuit is 220 / 5 +1 which comes to 45. The reference voltage on the LT3757 is 1.6V. 1.6 x 45 is only 72V. For correct gain to achieve 180V...