Shiva,
You're welcome. I'm glad to help you.
Perhaps your computer simulation program doesn't know the circuit's required functions:
1) U2 is supposed to be a classic "Sallen and Key equal-capacitor, equal resistor (requiring its gain of 1.6), Butterworth 2nd-order low pass filter" with a cutoff frequency of about 103Hz.
Your computer thinks that U2 can work fine open-loop, without any feedback, and amplify very much the noise from U1.
Your computer doesn't know that U1 and U2 probably have a small DC offset voltage. With an offset voltage at U2's input, its output would be idling against a power rail since its enormous gain would amplify very much this offset voltage. With its output idling against a power rail, then it becomes a high-gain rectifier with severe distortion.
2) U5 is supposed to be an earphone driver.
Your computer thinks that U5 can work fine without any feedback, with an open-loop gain of 100,000 or more, amplifying its own and other circuit noise.
Your computer doesn't know that the 741 opamp that is specified for U5 in the parts list is not capable of driving an 8 ohm to 32 ohm earphone, which is like a dead short to a 741.
Your computer doesn't know that the 741 that is specified for U5 will not work with its inputs DC referenced to its negative power supply.
3) This project is supposed to amplify low-frequency heart-beat sounds.
Your computer doesn't know that with the small value that is specified for C2 in the parts list, then the desired low frequencies are cutoff.
Etcetera. The simulation program doesn't know all the details.