Hi HC!
All these are good PCB layout softs, best way is to download a demo and try it yourself.
I use EAGLE which is simple to use I personally don't like big heavy softs that force you to use them dayily to keep the skills.
Never tried Proteus or Target 3000 myself but heard that they are good.
If you are a pro making PCB.s every day the best thing to do is to think over and over what your needs are, if not choose one that is easy to use and fulfil your needs don't take one just beacause lots of big companys use them these guys/ladys make PCB,s 8 hours/day.