Panelizing is done by machining a slot between two or more boards, but keep them attached by a small amount of PCB material (mousebites). I used to do it by hand: generated all the schematics into multiple sheets and then route the board and finally add the slots with mousebites in the PCB editor. I generally use slotwidth of 50 mil and the smallest drill possible (12 mil) 12.5 mil apart as breakingline. I tend to place the mousebites about 2cm from each other to maintain PCB strength.
Mike is the founder and editor of Electronics-Lab.com, an electronics engineering community/news and project sharing platform. He studied Electronics and Physics and enjoys everything that has moving electrons and fun. His interests lying on solar cells, microcontrollers and switchmode power supplies. Feel free to reach him for feedback, random tips or just to say hello :-)
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